The cell expansion market involves growth and cultivation of cells in a suitable nutrient culture medium in order to achieve the targeted number of cells. Cell expansion is required for various applications such as development of cell-based therapies, stem cell research, drug screening, and toxin and efficacy testing. The major advantages of cell expansion include maintaining cell morphology, character, viability and vitality as well as generating sufficient quantity of cells within short period of time. The growing demand for cell-based therapies drives the need for cell cultivation and expansion techniques.
The Global cell expansion market is estimated to be valued at US$ 16,035.5 Mn in 2024 and is expected to exhibit a CAGR of 11% over the forecast period 2023 to 2030.
Key Takeaways
Key players operating in the cell expansion market are Becton, Dickinson and Company, Sartorius AG, Merck KGaA, Corning, Inc., Eppendorf SE, Lonza Group AG, PromoCell, Danaher, Thermo Fisher Scientific, HiMedia Laboratories, STEMCELL Technologies Inc., REPROCELL Inc., Bio-Techne, Valiant Co., Ltd., Miltenyi Biotec, Biologos, Cyagen US Inc. Becton, Dickinson and Company holds a major share of around 25% in the global cell expansion market.
The growing demand for biopharmaceuticals, rising prevalence of lifestyle diseases and increasing investments in cell-based research are fueling the demand for cell expansion techniques. Advancements in cell cultivation tools such as bioreactors have accelerated the commercial cell production process.
Recent advancements in single-use bioreactors, microcarriers, perfusion systems and automated systems for cell cultivation have helped scale up cell production while reducing costs and improving yields. Continued developments in xenofree and animal-free cell expansion solutions are further expanding application areas.
Market Trends
Two key trends driving growth in the cell expansion market are rising demand for regenerative medicine and growing RD in advanced therapeutics. Regenerative medicine therapies involving stem cells require large quantities of cells which is fueling adoption of commercial cell expansion services. Advancements are also being made in 3D cell expansion methodologies for engineering complex human tissues.
Market Opportunities
Increasing investments in development of advanced cell-based therapies present a major opportunity for cell expansion market players. Biopharma companies are investing heavily in development of CAR-T therapies, immunotherapies and other advanced therapies. Setting up dedicated commercial cell production facilities especially for autologous CAR-T therapy represents a lucrative opportunity. Adoption of automated and closed cell expansion systems also presents an untapped growth potential.
Impact of COVID-19 on Cell Expansion Market Growth
The outbreak of COVID-19 pandemic has significantly impacted the growth of cell expansion market. Government imposed lockdowns and social distancing norms led to temporary closure of cancer research laboratories and cell therapy production facilities. This disrupted the ongoing research activities for development of novel cell therapies as well as commercial production of approved cell therapies. Supply chain disruptions further restricted the availability of key raw materials like growth factors and cytokines required for cell expansion processes. This negatively impacted the overall market growth particularly during 2020 and 2021.
However, with gradual relaxation of lockdown measures and resumption of business activities from 2022, the market is recovering steadily. Growing investment by pharmaceutical companies in development of cell therapies for conditions exacerbated by covid-19 like respiratory failure is fueling the demand. Increasing number of clinical trials evaluating the efficacy of mesenchymal stem cells and other progenitor cells in treatment of covid-19 complications is also boosting the market growth. Use of automation and single-use production systems aided continuity of cell production during pandemic. Development of novel 3D microfluidic expansion systems enabling large scale production with minimal manual intervention made cell therapy manufacturing relatively pandemic-proof. Ongoing technological advancements in cell expansion methodologies along with resumption of research activities are expected to support market recovery over the forecast period from 2023-2030.
Geographical Regions with Highest Concentration of Cell Expansion Market Value
North America holds the largest market share in terms of value, accounting for approximately 40% of global cell expansion market revenue. Presence of major pharmaceutical companies and large number of ongoing clinical research for developing novel cell therapies drives significant market growth in the region. Particularly United States represents the most lucrative market owing to availability of favorable regulatory framework and public-private investments supporting cell therapy research.
Europe is currently the second largest regional market, mainly concentrated in countries like Germany, United Kingdom and France. Established biotech clusters, skilled workforce and government funding for regenerative medicine projects have propelled Europe's position as a key market for cell expansion. Asia Pacific market is witnessing fastest growth and expected to overtake Europe by 2028. Rising biotechnology industry, increasing healthcare expenditure and presence of contract manufacturing organizations in China, India, South Korea and Japan offer significant growth opportunities in Asia Pacific region.
Europe represents the fastest growing regional market for cell expansion globally. Presence of world-class academic and research institutions, growing stem cell banking industry and initiatives promoting innovation are driving accelerated adoption of cell expansion methodologies across Europe. Countries like Germany and United Kingdom are emerging as innovation hubs for developing novel 3D microfluidic based expansion platforms. Increasing healthcare reimbursements for approved cell therapies also supports market growth. Significant investments by European Commission in development of advanced therapies collectively support Europe's position as the fastest growing market for cell expansion.
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