Profiling and in-depth characterization of glycosylated molecules in biotherapeutic and research samples require specialized equipment and focused expertise, which has prompted the research institutes, clinics and drug developers to outsource glyco-analytical operations to contract service providers, that claim to have the required skillset and technical infrastructure to assess multiple glycosylation attributes, such as glycan structure, position, linkage, charge and composition, in the minimum time. Further, glycans represent a promising class of biomarkers that are useful for disease prognosis, diagnosis, and assist in the glycosylation prediction of treatment efficacy
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Key Inclusions
- A detailed review of the overall landscape of the glycan analysis services market, highlighting the contributions of industry players, along with the information on their year of establishment, company size, geographical location of headquarters, type of service(s) offered (glycan profiling and heterogeneity analysis, glycosylation site mapping and occupancy analysis, site- specific glycosylation analysis, glycan structure analysis, monosaccharide quantification analysis and protein- glycan binding analysis), type of glycoconjugate and glycan analyzed (N- glycan, O- glycan and glycolipid), type of sample analyzed (biotherapeutics and cellular), type of analyte processed (intact glycoprotein, glycopeptide, released glycan, monosaccharide and polysaccharide), type of analytical technique used (chromatography, spectroscopy, electrophoresis and microarray- based technique), application area (RD / early- stage drug development and in- process drug development) It also provides information on the additional services offered (peptide mapping, post- translational modification analysis, protein terminal sequencing and glycan / glycoconjugate synthesis), and availability of synthetic glycans and analytical kits / tests. In addition, it provides information on the type of glycoanalytical service offered and type of technique used by non-industry players.
- A region-wise company competitiveness analysis, highlighting the most prominent glycan analysis service providers, based on their supplier strength (in terms of experience and company size), and portfolio specifications (in terms of number of services offered, number of analytical techniques used, types of glycans analyzed, types of analytes processed and applications).
- Elaborate profiles of prominent service providers in this domain. Each company profile includes a brief overview of the company, its financial information (if available), information on service portfolio, recent developments, and an informed future outlook.
- A detailed assessment of the current market landscape of surface glycan targeting therapeutics, providing information on the phase of development (commercial, clinical, preclinical, and discovery) of lead candidates, target disease indication and therapeutic area, type of drug molecule (antibody, antibody-drug conjugate, enzyme, glyco- conjugate vaccine and CAR- T cells), target glycan / glycoconjugate molecule, type of therapy (monotherapy, combination therapy and both), and technology platform used. In addition, it provides details on drug developer(s), including information on their year of establishment, company size, and location of headquarters.
- A detailed analysis of grants that have been awarded to research institutes for surface glycan targeting therapeutic projects, during the period, 2016 and 2021, based on several relevant parameters, such as year of grant award, amount awarded, administering institute center, support period, type of grant application, purpose of grant award, activity code, study section involved, type of recipient organizations and focus area. In addition, it highlights geographical distribution of recipient organizations, popular funding institute centers, prominent program officers, and popular recipient organizations.
- An analysis of the partnerships that have been established in this domain since 2015, covering instances of acquisitions and mergers, licensing agreements, product development agreements, process development agreement, research agreements, and other relevant types of deals.
- A detailed analysis of the various mergers and acquisitions that have taken place in this domain, highlighting the trend in the number of companies acquired during the time period between 2015- 2021, based on several relevant parameters, such as year of agreement, type of deal, geographical location of headquarters, company size, and the key value drivers. In addition, it represents an ownership change matrix, providing a summary of the involvement of private and public sector entities in this domain.
- A case study on the potential clients of glycan analysis services providers; it presents a list of Fc glycoengineered antibody developers, along with information on their year of establishment, company size, and location of headquarters. In addition, it provides information on the type of glycoengineered antibody, target molecule, technology platform used, phase of development, target disease indication and therapeutic area, type of therapy, line of treatment and route of administration.
systems used (mammalian, microbial and others), and affiliations to regulatory agencies
The report features the likely distribution of the current and forecasted opportunity across important antibody purification services market segments, mentioned below:
- Company Size
- Small Companies
- Mid-sized Companies
- Large Companies
- Type of Analytical Technique
- Spectroscopy- based
- Chromatography- based
- Microarray- based
- Electrophoresis- based
- Key Geographical Regions
- North America
- Europe
- Asia- Pacific and the Rest of the World
The report also features inputs from eminent industry stakeholders, according to whom, growing pipeline of glycoprotein therapies and stringent standards for glyco- analytical operations, set up by the regulatory agencies are driving the growth of the glycosylation analysis services market. The report includes detailed transcripts of discussions held with the following experts:
- Biswa Choudhury (Technical Director, GlycoAnalytics Core, University of California)
- Erdmann Rapp (Chief Executive Officer, glyXera)
- Juhani Saarinen (Chief Executive Officer, Glykos Finland)
Key Questions Answered
- Who are the leading industry and non- industry players offering glycan analysis services?
- Which are the key geographies where glycan analysis service providers are located?
- What are the common analytical techniques used by the service providers?
- What are the prevalent RD trends related to surface glycan targeting therapies?
- Which surface glycan molecules are targeted by such therapies?
- What are the key therapeutic areas for which such therapies are being / have been developed?
- Who are the leading players engaged in the development of surface glycan targeting therapies?
- Which partnership models are commonly adopted by stakeholders in this industry?
- What are the key value drivers of the merger and acquisition activity within this domain?
- How is the current and future opportunity, related to glycan analysis services, likely to be distributed across key market segments?
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